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KMID : 0861020100250010001
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Korea Journal of Herbology
2010 Volume.25 No. 1 p.1 ~ p.7
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A Chromosome Aberration Test of HMC05 on Cultured Chinese Hamster Lung Cells
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Shin Heung-Mook
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Abstract
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Objectives: We investigated genetic toxicity of HMCO5 in relation to chromosome aberration test on Cultured Chinese Hamster Lung (CHL) in the presence and absence of S-9 mix.
Methods: Experimental groups were divided into two groups: with S-9mix (+S) or without S-9 mix (-S). -S group was also divided 2 series by treatment hours (6 hr: 6-S; or 24 hr; 24-S). Each group treated with vehicle only (complete culture medium), HMCO5 (1,250, 2,500, 5,000 ㎍/㎖), and cyclophosphamide monohydrate (CPA) and ethylmethanesulfonate (EMS), respectively.
Results: HMC05 did not show any aberrant metaphase. However, there were significant (p < 0.01) aberrant metaphases with CPA in S+ and with EMS in S-.
Conclusions: These results indicate that HMC05 fomula does not show any toxicity in chromosome aberration test.
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KEYWORD
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Genetic toxicity, HMC05, Chinese Hamster Lung cells, chromosome aberration test
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